Arabinogalactan is a water-soluble polysaccharide found in many foods such as carrots and radishes. However, uniquely high concentrations of this fiber are found in the bark of the western Larch Tree (Latrix occidentalis). The source of Biotics Research's product "IAG" Arabinogalactan.
How Does Arabinogalactan provide immune support?
Arabinogalactan has been shown to have a positive impact on the human immune system.
Human studies, conducted at several major U. S. universities, showed increased immune cell proliferation at consumption levels of about 1500 mg of Arabinogalactan per day.
Natural Killer Cell (NK) and Macrophage Activation
Arabinogalactans' enhancement of NK cells' ability to destroy foreign cells (cytotoxicity) is not initiated by arabinogalactans directly but is governed by the cytokine network (cells talking to cells.) Larch arabinogalactans induce an increased release of cell-to-cell messengers, interferon gamma (IFN gamma), tumor necrosis factor alpha, interleukin-1 beta (IL-1 beta) and IL-6. IFN gamma is the one involved in enhancement of NK cytotoxicity. Studies indicates that larch arabinogalactans presumably interact with a receptor on the cell wall that is specific for an oligosaccharide known to enhance a NK-cytotoxicity.
Low to middle MW (5,000-50,000) arabinogalactan polysaccharides have strong immuno-stimulating properties with simultaneous anti-inflammatory properties. The surprising anti-inflammatory effects are especially protective against radiation and allergies in oral doses as low as 20-50mg.
Arabinogalactans decrease viral load by inhibiting viral duplication.
Effects in Metastatic Disease
Malignancies commonly spread to the liver, in preference to other organ sites. Several studies have compellingly shown that arabinogalactan inhibits this reaction. Larch arabinogalactan has been studied in experimental models of metastatic disease spread to the liver, including its use in conjunction with modified citrus pectin. Both polysaccharides work in essentially the same way, that is, by inhibiting the attachment of metastatic cells to liver parenchyma by competitive binding to a liver lectin, the hepatic galactose receptor. Arabinogalactan blockades potential liver receptors by covering galactose-specific binding sites. Arabinogalactan appear to also have the ability to completely prevent the settling of certain tumors in the liver. Therefore, when lectins are blocked with competitive specific glycoconjugates (the arabinogalactans), colonization may be prevented.
Larch arabinogalactan is also an excellent source of dietary fiber, and has been shown to increase the production of short-chain fatty acids (SCFA), principally butyric acid. Larch arabinogalactans are easily digested by human colonic bacteria to yield butyrate. Butyrate (formed from butyric acid) has a particularly important role in the colon. It is the preferred source of energy for cells lining the colon (colonic epithelial cells). Butyrate has also been shown to protect these cells against mutagenic agents. (Pectin and arabinogalactan - both in Green Vibrance, by the way - also decrease ammonia generation.)
E. coli Adherence
Arabinogalactans are useful for therapeutic treatment of infections caused by pathogenic microorganisms, particularly intestinal bacteria, such as Gram-negative types. Specifically we are talking of the Enterobacteriaceae type such as Escherichia coli bacteria (E. coli). Arabinogalactans have dramatically inhibit bacterial adherence and, therefore, colonization.
Our IAG is in powder form, which is convenient for me to put into my infant son's formula.