Sunday, December 20, 2009

10 Facts about Fluoride

10 Facts about Fluoride
Fluoride Action Network | December 2006


1) 97% of western Europe has chosen fluoride-free water. This includes: Austria, Belgium, Denmark, Finland, France, Germany, Iceland, Italy, Luxembourg, Netherlands, Northern Ireland, Norway, Scotland, Sweden, and Switzerland. (While some European countries add fluoride to salt, the majority do not.) Thus, rather than mandating fluoride treatment for the whole population, western Europe allows individuals the right to choose, or refuse, fluoride.


2) Fluoride is the only chemical added to drinking water for the purpose of medication (to prevent tooth decay). All other treatment chemicals are added to treat the water (to improve the water's quality and safety - which fluoride does not do). This is one of the reasons why most of Europe has rejected fluoridation. For instance:

In Germany, "The argumentation of the Federal Ministry of Health against a general permission of fluoridation of drinking water is the problematic nature of compulsion medication."

In Belgium, it is "the fundamental position of the drinking water sector that it is not its task to deliver medicinal treatment to people. This is the sole responsibility of health services."

In Luxembourg, "In our views, drinking water isn't the suitable way for medicinal treatment and that people needing an addition of fluoride can decide by their own to use the most appropriate way."


3) Contrary to previous belief, fluoride has minimal benefit when swallowed. When water fluoridation began in the 1940s and '50s, dentists believed that fluoride needed to be swallowed in order to be most effective. This belief, however, has now been discredited by an extensive body of modern research (1).

According to the Centers for Disease Control, fluoride's "predominant effect is posteruptive and topical" (2). In other words, any benefits that accrue from the use of fluoride, come from the direct application of fluoride to the outside of teeth (after they have erupted into the mouth) and not from ingestion. There is no need, therefore, to expose all other tissues to fluoride by swallowing it.


4) Fluoridated water is no longer recommended for babies. In November of 2006, the American Dental Association (ADA) advised that parents should avoid giving babies fluoridated water (3). Other dental researchers have made similar recommendations over the past decade (4).

Babies exposed to fluoride are at high risk of developing dental fluorosis - a permanent tooth defect caused by fluoride damaging the cells which form the teeth (5). Other tissues in the body may also be affected by early-life exposures to fluoride. According to a recent review published in the medical journal The Lancet, fluoride may damage the developing brain, causing learning deficits and other problems (6).


5)There are better ways of delivering fluoride than adding it to water. By adding fluoride to everyone's tap water, many infants and other at-risk populations will be put in harm's way. This is not only wrong, it is unnecessary. As western Europe has demonstrated, there are many equally effective and less-intrusive ways of delivering fluoride to people who actually want it. For example:

A) Topical fluoride products such as toothpaste and mouthrinses (which come with explicit instructions not to swallow) are readily available at all grocery stores and pharmacies. Thus, for those individuals who wish to use fluoride, it is very easy to find and very inexpensive to buy.

B) If there is concern that some people in the community cannot afford to purchase fluoride toothpaste (a family-size tube of toothpaste costs as little as $2 to $3), the money saved by not fluoridating the water can be spent subsidizing topical fluoride products (or non-fluoride alternatives) for those families in need.

C) The vast majority of fluoride added to water supplies is wasted, since over 99% of tap water is not actually consumed by a human being. It is used instead to wash cars, water the lawn, wash dishes, flush toilets, etc.


6) Ingestion of fluoride has little benefit, but many risks. Whereas fluoride's benefits come from topical contact with teeth, its risks to health (which involve many more tissues than the teeth) result from being swallowed.

Adverse effects from fluoride ingestion have been associated with doses atttainable by people living in fluoridated areas. For example:

a) Risk to the brain. According to the National Research Council (NRC), fluoride can damage the brain. Animal studies conducted in the 1990s by EPA scientists found dementia-like effects at the same concentration (1 ppm) used to fluoridate water, while human studies have found adverse effects on IQ at levels as low as 0.9 ppm among children with nutrient deficiencies, and 1.8 ppm among children with adequate nutrient intake. (7-10)

b) Risk to the thyroid gland. According to the NRC, fluoride is an “endocrine disrupter.” Most notably, the NRC has warned that doses of fluoride (0.01-0.03 mg/kg/day) achievable by drinking fluoridated water, may reduce the function of the thyroid among individuals with low-iodine intake. Reduction of thyroid activity can lead to loss of mental acuity, depression and weight gain (11)

c) Risk to bones. According to the NRC, fluoride can diminish bone strength and increase the risk for bone fracture. While the NRC was unable to determine what level of fluoride is safe for bones, it noted that the best available information suggests that fracture risk may be increased at levels as low 1.5 ppm, which is only slightly higher than the concentration (0.7-1.2 ppm) added to water for fluoridation. (12)

d) Risk for bone cancer. Animal and human studies – including a recent study from a team of Harvard scientists – have found a connection between fluoride and a serious form of bone cancer (osteosarcoma) in males under the age of 20. The connection between fluoride and osteosarcoma has been described by the National Toxicology Program as "biologically plausible." Up to half of adolescents who develop osteosarcoma die within a few years of diagnosis. (13-16)

e) Risk to kidney patients. People with kidney disease have a heightened susceptibility to fluoride toxicity. The heightened risk stems from an impaired ability to excrete fluoride from the body. As a result, toxic levels of fluoride can accumulate in the bones, intensify the toxicity of aluminum build-up, and cause or exacerbate a painful bone disease known as renal osteodystrophy. (17-19)


7) The industrial chemicals used to fluoridate water may present unique health risks not found with naturally-occurring fluoride complexes . The chemicals - fluorosilicic acid, sodium silicofluoride, and sodium fluoride - used to fluoridate drinking water are industrial waste products from the phosphate fertilizer industry. Of these chemicals, fluorosilicic acid (FSA) is the most widely used. FSA is a corrosive acid which has been linked to higher blood lead levels in children. A recent study from the University of North Carolina found that FSA can - in combination with chlorinated compounds - leach lead from brass joints in water pipes, while a recent study from the University of Maryland suggests that the effect of fluoridation chemicals on blood lead levels may be greatest in houses built prior to 1946. Lead is a neurotoxin that can cause learning disabilities and behavioral problems in children. (20-23)


8) Water fluoridation’s benefits to teeth have been exaggerated. Even proponents of water fluoridation admit that it is not as effective as it was once claimed to be. While proponents still believe in its effectiveness, a growing number of studies strongly question this assessment. (24-46) According to a systematic review published by the Ontario Ministry of Health and Long Term Care, "The magnitude of [fluoridation's] effect is not large in absolute terms, is often not statistically significant and may not be of clinical significance." (36)

a) No difference exists in tooth decay between fluoridated & unfluoridated countries. While water fluoridation is often credited with causing the reduction in tooth decay that has occurred in the US over the past 50 years, the same reductions in tooth decay have occurred in all western countries, most of which have never added fluoride to their water. The vast majority of western Europe has rejected water fluoridation. Yet, according to comprehensive data from the World Health Organization, their tooth decay rates are just as low, and, in fact, often lower than the tooth decay rates in the US. (25, 35, 44)

b) Cavities do not increase when fluoridation stops. In contrast to earlier findings, five studies published since 2000 have reported no increase in tooth decay in communities which have ended fluoridation. (37-41)

c) Fluoridation does not prevent oral health crises in low-income areas. While some allege that fluoridation is especially effective for low-income communities, there is very little evidence to support this claim. According to a recent systematic review from the British government, "The evidence about [fluoridation] reducing inequalities in dental health was of poor quality, contradictory and unreliable." (45) In the United States, severe dental crises are occurring in low-income areas irrespective of whether the community has fluoride added to its water supply. (46) In addition, several studies have confirmed that the incidence of severe tooth decay in children (“baby bottle tooth decay”) is not significantly different in fluoridated vs unfluoridated areas. (27,32,42) Thus, despite some emotionally-based claims to the contrary, water fluoridation does not prevent the oral health problems related to poverty and lack of dental-care access.


9) Fluoridation poses added burden and risk to low-income communities. Rather than being particularly beneficial to low-income communities, fluoridation is particularly burdensome and harmful. For example:

a) Low-income families are least able to avoid fluoridated water. Due to the high costs of buying bottled water or expensive water filters, low-income households will be least able to avoid fluoride once it's added to the water. As a result, low-income families will be least capable of following ADA’s recommendation that infants should not receive fluoridated water. This may explain why African American children have been found to suffer the highest rates of disfiguring dental fluorosis in the US. (47)

b) Low-income families at greater risk of fluoride toxicity. In addition, it is now well established that individuals with inadequate nutrient intake have a significantly increased susceptibility to fluoride’s toxic effects. (48-51) Since nutrient deficiencies are most common in income communities, and since diseases known to increase susceptibility to fluoride are most prevalent in low-income areas (e.g. end-stage renal failure), it is likely that low-income communities will be at greatest risk from suffering adverse effects associated with fluoride exposure. According to Dr. Kathleen Thiessen, a member of the National Research Council's review of fluoride toxicity: “I would expect low-income communities to be more vulnerable to at least some of the effects of drinking fluoridated water." (51)


10) Due to other sources, many people are being over-exposed to fluoride . Unlike when water fluoridation first began, Americans are now receiving fluoride from many other sources* besides the water supply. As a result many people are now exceeding the recommended daily intake, putting them at elevated risk of suffering toxic effects. For example, many children ingest more fluoride from toothpaste alone than is considered “optimal” for a full day’s worth of ingestion. According to the Journal of Public Health Dentistry:

"Virtually all authors have noted that some children could ingest more fluoride from [toothpaste] alone than is recommended as a total daily fluoride ingestion." (52)

Because of the increase in fluoride exposure from all sources combined, the rate of dental fluorosis (a visible indicator of over-exposure to fluoride during childhood) has increased significantly over the past 50 years. Whereas dental fluorosis used to impact less than 10% of children in the 1940s, the latest national survey found that it now affects over 30% of children. (47, 53)

* Sources of fluoride include: fluoride dental products, fluoride pesticides, fluorinated pharmaceuticals, processed foods made with fluoridated water, and tea.


References

To access the references, click here

Friday, December 11, 2009

Tests Find More Than 200 Chemicals in Newborn Umbilical Cord Blood

Tests Find More Than 200 Chemicals in Newborn Umbilical Cord Blood

Study commissioned by environmental group finds high levels of chemicals in U.S. minority infants

By Sara Goodman

newborn-chemical-umbilical-cord-environmental-working-group

TOXIC INHERITANCE: Babies are born with a slew of potentially dangerous chemicals.
ISTOCKPHOTO/RAPIDEYE

U.S. minority infants are born carrying hundreds of chemicals in their bodies, according to a report released today by an environmental group.

The Environmental Working Group's study commissioned five laboratories to examine the umbilical cord blood of 10 babies of African-American, Hispanic and Asian heritage and found more than 200 chemicals in each newborn.

"We know the developing fetus is one of the most vulnerable populations, if not the most vulnerable, to environmental exposure," said Anila Jacobs, EWG senior scientist. "Their organ systems aren't mature and their detox methods are not in place, so cord blood gives us a good picture of exposure during this most vulnerable time of life."

Of particular concern to Jacobs: 21 newly detected contaminants, including the controversial plastics additive bisphenol A, or BPA, which mimics estrogen and has been shown to cause developmental problems and precancerous growth in animals. Last month, researchers reported that male Chinese factory workers exposed to high levels of the chemical experienced erectile dysfunction and other sexual problems.

"BPA is a really important finding because people are really aware about its potential toxicity," Jacobs told reporters. "This is the first study to find BPA in umbilical cord blood, and it correlates with national data on it."

Jacobs said the study focused on minority children to show that chemical exposure is ubiquitous, building on 2005 research on cord blood from 10 anonymous babies. That study found a similar body burden among the babies. This is the first study to look at chemicals in minority newborns.

"Minority groups may have increased exposure to certain chemicals, but here we didn't focus on those chemicals," Jacobs said. "The sample size is too small to see major differences, but we want to increase awareness about chemical exposures."

Leo Trasande, co-director of the Children's Environmental Health Center at the Mount Sinai School of Medicine, said the findings, while preliminary, show that minority communities are often disproportionately affected by chemical exposure. Trasande was not involved in the EWG study.

"Presently, minority communities suffer from a host of chronic disorders, and disproportionate chemical exposures may contribute significantly to the origins of the disparities that exist," Trasande said.

Both he and Jacobs said the findings add momentum for the call to revamp the Toxic Substances Control Act, or TSCA, the law regulating the more than 80,000 chemicals on its database. They released the report on the same day that a Senate panel is scheduled to discuss the government's strategy for managing the tens of thousands of chemicals in the marketplace with an eye toward overhauling TSCA.

TSCA does not require most chemicals to be tested for safety before they are approved for widespread use. Because of this, Trasande said, less than half of the 3,000 high-production volume chemicals on the marketplace have toxicity data, and less than one-fifth have toxicity testing data on the effects on developing organs.

Wednesday, November 25, 2009

Caffeine hurts your unborn baby, ADD

Coffee & Caffeine During Pregnancy

Links to Learning Disabilities, ADD and Behavior Disorders

INTRODUCTION

A very large review of the coffee/caffeine research was presented by French researcher, Dr. Astrid Nehlig, in the 1994 journal Neurotoxicology and Teratology. His review summarized over 200 medical journal articles on the coffee/caffeine subject. Below are what we consider to be the most significant quotes from Dr. Nehlig’s article:

"The teratogenic effect of caffeine has been clearly demonstrated in rodents. However, rodents are much more sensitive than primates to the teratogenic effects of many substances. Moreover, the quantity of caffeine needed to induce malformations in rodents reaches doses that are toxic in man. Thus a woman weighing 60 kg would have to consume 50-70 cups of coffee per day (or at least 20 cups if interspecific metabolic variations are taken into account) to absorb the equivalent of 80-100 mg/kg/day of caffeine, which is the dose usually required for development of malformations rats."

"World coffee consumption is increasing. Analyzing the data from surveys carried out in the United States, Japan, and West Germany for the period of 1980-1991, it appears that the number of coffee drinkers has decreased by 2-5% in three countries, while coffee consumption, in terms of number of cups/consumer/day has increased in each country."

"A mean size cup (150 ml) of caffeinated coffee contains in general about 90 mg of caffeine and 63 mg of caffeine for soluble instant coffee. The same volume of decaffeinated coffee contains 3 mg of caffeine, whereas the content of caffeine reaches 32-42 mg in 150 ml of tea and 16 mg in 150 ml of cola drinks."

"The daily consumption of caffeine in the general population ranges from 202-283 mg of caffeine which represents 2.7-4.0 mg/kg/day in males and females 20-75 years old."

"The half life of caffeine ranges from .7 -1.2 hours in the rat and mouse, 3-5 hours in the monkey and 2.5-6 hours in humans."

"Caffeine half-life is increased in the neonatal period in both animals and humans due to the immaturity of hepatic (liver) enzyme systems, namely cytochrome P-450. Half lives of 40-130 hours are found in premature and newborn infants. They decrease rapidly to 14.4 and 2.6 hours in 3-5 month and 5-6 month infants, respectively. Longer half-lives of caffeine are found in breast-fed than in formula fed infants."

"The U.S. Food and Drug Administration published a warning in 1980 advising pregnant women to restrict or even eliminate consumption of coffee given the teratogenic effect (the ability to cause birth defects) observed in rodents."

"Finally, in comparing results of drug administration in both humans and animals, a correction factor for the dose must be applied, also called metabolic body weight. Indeed, dose equivalents based on metabolic body weight are substantially lower than those based on body weight: 20 mg/kg in the rat is equivalent to about 17 cups of coffee (at 100 mg/cup) in a 70-kg man on a body weight basis, but only 4 - 6 cups when corrections are made for differences in metabolic body weight."

"In the monkey, spontaneous abortions and stillbirths have been recorded at the 2 doses used, 10-15 and 25-35 mg/kg/day of caffeine. (Equivalent to 2-3 cups and 5-8 cups of coffee, respectively). In humans, coffee and caffeine consumption from other sources have been associated with a higher incidence of spontaneous abortions (in 5 studies."

"The association between coffee and/or caffeine intake and prematurity seems then to be very weak, or absent. According to one study, 11% of the spontaneous abortions can be attributed to smoking, 5% to alcohol, and only 2% to coffee."

"The risk for any kind of congenital abnormalities is 3.7% in individuals who consume caffeine and 1.7% in those who do not. The difference is statistically significant."

"It has also been shown that absorption of caffeine has a vasoconstrictive effect on placental circulation. Blood flow is not modified in the umbilical fetal vein but intervillious placental blood flow is significantly diminished after absorption of 2 cups of coffee. This decrease in blood flow along with increased concentration of noradrenaline induced by caffeine in the maternal serum could represent a potential risk for the fetus."

"Caffeine diffuses through the placenta and accumulates in the brain of the fetus (3 studies) Caffeine concentration of the fetal rat is higher in the brain than in the placenta whereas the metabolites of methylxanthine are evenly distributed between brain and placenta."

"Exposure of female rats to caffeine during pregnancy (.04% in drinking water) causes proportionally greater loss in brain weight than in body weight (3 studies)."

"When pregnant rats ingest 10-20 mg/kg day caffeine, the cerebral concentrations of these various elements are lower in offspring at birth."

"Exposure to caffeine during gestation and lactation (.04% in drinking water) also induces modifications in cerebral concentrations of catecholamines, tyrosine, tryptophan, serotonin, 5-hydroxyindole acetic aid, and cyclic nucleotides in the brain of 1 - 35 day old rat (4 studies), which can cause behavioral abnormalities, such as hypoactivity, during development of the animal."

"...Thus, it seems that early caffeine exposure, even at quite low doses, is able to induce a wide variety of neurochemical changes. These deficits concern both constitutive material such as proteins, DNA and RNA, and functional material such as neurotransmitters and ions."

"Offspring of female rats exposed to 60 or 100 mg/kg caffeine in their drinking water throughout gestation have reduced learning capacities as adults in a novel environment. In an open field, these animals also spend less time grooming, playing, and touching new objects. The authors concluded that the behavioral effects induced by prenatal caffeine exposure could be related to the "hyperactive" children syndrome (Sinton, C. M. et. al., 1981)."




--------------------------------------------------------------------------------

Smaller Head Circumference –

Lower Birth Weight After 300 mg Caffeine Intake

Source: Neurobehavioral Toxicology and Teratology, Vol. 7:9-17, 1985

Although 300 mg of caffeine intake represents approximately 2 or 3 cups of coffee, many people don’t realize the amount of caffeine they can consume from other sources besides coffee. Most studies, such as the ones previously mentioned, look for toxic effects based on the number of cups of coffee consumed per day. However, if significant amounts of caffeine can be ingested from other sources besides coffee, this could hide the true dangers when comparing coffee drinkers with non-coffee drinkers.

In this 1983 Ottawa study at Carleton University, Canada, the researchers analyzed the total caffeine intake from all sources in 286 pregnant women. For the first trimester of their pregnancy, coffee accounted for only 56% of their total caffeine intake, tea accounted for 37% of caffeine intake, while caffeinated soft drinks, chocolate bars, chocolate drinks and caffeinated medications accounted for approximately 7% of caffeine intake. These levels maintained about the same throughout pregnancy.

Approximately 4% of the women during pregnancy consumed 100 - 300 mg of coffee daily while 4% of the group consumed over 300 mg of coffee daily.

The researchers stated,

"The most marked effect associated with heavy caffeine use (over 300 mg daily) in the present study were the reduced birth weight and the smaller head circumference that persisted after statistically controlling for other potentially contributing factors."

The mean head circumference of the infants born to the heavier caffeine users was 1.1 centimeters (cm) smaller when compared to those consuming under 300 mg of caffeine daily (33.5 cm compared with 34.6 cm, respectively). This difference was considered significant. A significant decrease of 379 grams in average birth weight was also observed in the heavier caffeine group. The average weight of infants born to the heavier caffeine users was less than women consuming little caffeine (3537 grams for the low caffeine users and 3158 for the heavy caffeine user- nearly a 400 gram difference).

In summary, the researchers stated,

"It is during the last trimester of pregnancy that the greatest spurt in fetal growth occurs. The present results suggest that daily caffeine intake of 300 mg or more can interfere with normal fetal growth... The observed, relatively small birth weight reductions may be of minor importance to a healthy full-term baby of acceptable weight but may be of major clinical significance for a preterm or small infant."

Drs. B. Watkinson and P. A. Fried
Carleton University, Ottawa, Ontario, Canada
Maternal Caffeine Use Before, During and After Pregnancy and Effects Upon Offspring
Neurobehavioral Toxicology and Teratology, Vol. 7:9-17, 1985




--------------------------------------------------------------------------------

Caffeine Exposure Increases Learning Problems and Hyperactivity
in Laboratory Mice

Abstract: Dams from two strains of mice, were treated during gestation with caffeine, at doses of about 60, 80, and 100 mg/kg/day, in their drinking water. The resulting offspring were behaviorally tested over a 6 month period commencing at age 9 months. When compared with controls, mice from dams that had received caffeine demonstrated longer latencies in passive avoidance test, and differences were also noted for female offspring in activity and habituation measures. Having controlled as far as possible for post natal maternal and environmental effects, the most likely conclusion is that caffeine has a direct pharmacological action on the fetus, and should therefore be classed as a behavioral teratogen in mice.

Monday, November 23, 2009

ADHD and Natural Therapies

ADHD and Natural Therapies PDF Print E-mail



A small pilot study was published in the Journal of Alternative and Complementary Medicine (2007 Dec;13(10):1091-7). The idea was to treat the 10 subjects with multiple natural therapies, including chelation, nutrition, environmental control, behavioral therapy, speech therapy, physical therapy and educational therapy. The subjects were aged 4-10 and had been diagnosed with autism spectrum disorder and with ADHD. They were treated with a comprehensive program of natural therapies for 3-6 months. The results were judged by doctors, teachers and parents and all ten children demonstrated significant improvement in language skills, writing, behavior and social interaction. Also, urinary lead levels dropped in all of the subjects.

Granted, this was a small study. It was not double-blind or placebo controlled. It does, however bring up the interesting possibility that children with ADHD may respond to a comprehensive program of natural therapies. It makes sense to use a multi-faceted approach and try to develop a safe and natural way to address this complex problem. A larger, objective study would be interesting to see.

Migraine Headaches and Magnesium

A study appearing in Cephalalgia (1993;13:94-98) looked at magnesium levels in patients with migraine headaches and compared them to healthy controls. There were 30 patients who had migraine headaches with aura, 60 without aura and 30 healthy controls. The amount of magnesium in the red blood cells was measured. The migraine sufferers had significantly lower magnesium levels than did the subjects without headaches.